| 货号 | 5479/50 |
| 别名 | N-[[(1,2,3,5,6,7-Hexahydro-s-indace |
| 供应商 | Tocris |
| 生物活性 | Potent NLRP3 inflammasome inhibitor; inhibits IL-1β production (IC50 = 7.5 nM). Selective for NLRP3 inflammasome over NLRC4 inflammasome and Toll-like receptor signaling. Reduces severity of experimental autoimmune encephalomyelitis in mice. Also glutathione S-transferase omega 1 inhibitor. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >97 % |
| 计算分子量 | 426.46 |
| 分子式 | C20H23N2NaO5 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Collet al (2015) A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat.Med. 21 248. PMID: 25686105. Collet al (2011) The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes. PLoS ONE 6 e29539. PMID: 22216309. Laliberteet al (2003) Glutathione S-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1β posttranslational processing. J.Biol.Chem. 278 16567. PMID: 12624100. |