CLP 257 (50 MG)
货号：
5242/50 基本售价：
11233.1 元 规格：
50 mg
产品信息
概述| 货号 | 5242/50 |
| 别名 | (5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone |
性能| 供应商 | Tocris |
| 生物活性 | Selective KCC2 K+-Cl- cotransporter activator (EC50 = 616 nM). Exhibits selectivity for KCC2 over other KCC family members, NKCC1 and GABAA receptors, as well as 55 other receptors. Enhances Cl- transport and increases KCC2 plasma membrane expression in spinal slices with reduced KCC2 function. Alleviates hypersensitivity in rats with peripheral nerve injury. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 307.34 |
| 分子式 | C14H14FN3O2< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Gagnonet al (2013) Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat.Med. 19 1524. PMID: 24097188. |
