| 货号 | 1499/50 |
| 别名 | 5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl) |
| 供应商 | Tocris |
| 生物活性 | Potent and highly selective β3-adrenoceptor agonist (EC50 = 3 nM); > 10000-fold selective over β1andβ2 receptors. Increases brown adipose tissue thermogenesis and metabolic rate, and decreases blood insulin and glucose levels following oral administration in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 465.8 |
| 分子式 | C20H18ClNNa2O7 |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 151126-84-0 |
| 参考文献 | Woodset al (2001) Efficacy of the β3-adrenergic receptor agonist CL-316243 on experimental bladder hyperflexia and detrusor instability in the rat. J.Urol. 166 1142. PMID: 11490313. Yoshidaet al (1994) Anti-obesity and anti-diabetic effects of CL 316,243, a highly specific β3-adrenoceptor agonist, in yellow KK mice. Life Sci. 54 491. PMID: 8309351. Bloomet al (1992) Disodium(R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent β-adrenergic agonist virtually specific for β3 receptors. A promising antidiabetic and antiobesity agent. J.Med.Chem. 35 3081. PMID: 1354264. |