| 货号 | 5329/50 |
| 别名 | N-(2-Aminoethyl)-5-chloro-8-isoquin |
| 供应商 | Tocris |
| 生物活性 | Casein kinase 1 (CK1) inhibitor. Also inhibits SGK, S6K1 and MSK1. Induces retinal cell differentiation from human ESCs and iPSCs in combination with SB 431542 (Cat. No. 1614) and Y-27632 (Cat. No. 1254). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 358.67 |
| 分子式 | C11H12ClN3O2 |
| 可溶性/溶解性 | Soluble to 20 mM in water and to 50 mM in DMSO |
| 参考文献 | Osakadaet al (2009) In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J.Cell Sci. 122 3169. PMID: 19671662. Peiferet al (2009) 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38α mitogen activated protein kinase and casein kinase 1δ. J.Med.Chem. 52 7618. PMID: 19591487. Renaet al (2004) D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep. 5 60. PMID: 14710188. |