| 货号 | 3364/50 |
| 别名 | 2-(Hexahydro-4-methyl-1H-1,4-diazep |
| 供应商 | Tocris |
| 生物活性 | GLP and G9a histone lysine methyltransferase inhibitor (IC50 values are 0.7 and 1.7 μM respectively) that displays no activity at other histone methyltransferases up to 37 μM. Modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 600.02 |
| 分子式 | C28H38N6O2.3HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| CAS号 | 935693-62-2 |
| 参考文献 | Malmquistet al (2012) Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum. Proc.Natl.Acad.Sci.U S A 109 16708. PMID: 23011794. Changet al (2009) Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat.Struct.Mol.Biol. 16 312. PMID: 19219047. Shiet al (2008) Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 3 568. PMID: 18983970. Kubiceket al (2007) Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol.Cell 25 473. PMID: 17289593. |