| 货号 | 4472/50 |
| 别名 | 2-[[6-Amino-3,5-dicyano-4-[4-(cyclo |
| 供应商 | Tocris |
| 生物活性 | Potent adenosine A2B receptor agonist (EC50 = 2.83 nM for murine A2B receptor). Displays selectivity for A2B over A1, A2Aand A3 receptors. Decreases fMLP-induced superoxide production in neutrophils at low concentrations (1-10 nM). Cardioprotective; attenuates infarct size in a mouse model of myocardial ischemia. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 379.44 |
| 分子式 | C19H17N5O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | van der Hoevenet al (2011) A role for the low-affinity A2B adenosine receptor in regulating superoxide generation by murine neutrophils. J.Pharmacol.Exp.Ther. 338 1004. PMID: 21693629. Auchampachet al (2009) Characterization of the A2B adenosine receptor from mouse, rabbit, and dog. J.Pharmacol.Exp.Ther. 329 2. PMID: 19141710. Eckleet al (2007) Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors. Circulation 115 1581. PMID: 17353435. |