| 货号 | 5491/50 |
| 别名 | (αS,γS,δS,ζS)-δ-Amino-N-(3-amino-2,2-dim |
| 供应商 | Tocris |
| 生物活性 | Potent renin inhibitor (IC50 = 0.6 and 80 nM for human and rat respectively). Exhibits selectivity for renin over a range of other aspartic proteinases (>5000 nM). Lowers blood pressure in a hypertensive rodent model. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 609.83 |
| 分子式 | C30H53N3O6.1/2C |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Kaye and Krum (2007) Drug discovery for heart failure: a new era or the end of the pipeline? Nat.Rev.Drug Discov. 6 127. PMID: 17268484. Jensenet al (2) Aliskiren: the first renin inhibitor for clinical treatment. Nat.Rev.Drug Discov. 7 399. PMID: 18340340. |