| 货号 | 5462/50 |
| 别名 | N,N,N-Triethyl-2-oxo-2-[[4-[2-[4-[( |
| 供应商 | Tocris |
| 生物活性 | Photoswitchable Kv channel blocker (IC50 values are 2 and 64 μM at 500 nm and 380 nm respectively). Switches conformation from cistotrans at 500 nm and transtocis at 380 nm. Exhibits minimal activity at Nav1.2 and L-type Ca2+ channels. Stimulates action potential firing of hippocampal neurons in vitro at 500 nm and restores visual responsiveness in blind mice at 380 nm. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 443.97 |
| 分子式 | C23H30ClN5O2 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Polosukhinaet al (2012) Photochemical restoration of visual responses in blind mice. Neuron 75 271. PMID: 22841312. Banghartet al (2009) Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 48 9097. PMID: 19882609. Fortinet al (2008) Photochemical control of endogenous ion channels and cellular excitability. Nat.Methods 5 331. PMID: 18311146. |