| 货号 | 4571/50 |
| 别名 | 4-[5-(4-Chlorophenyl)-2-methyl-3-(1 |
| 供应商 | Tocris |
| 生物活性 | Positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X. laevis oocytes). Displays no activity at 5-HT3A,α3β4 or α4β2 nAChRs. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >97 % |
| 计算分子量 | 402.89 |
| 分子式 | C20H19ClN2O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming |
| 参考文献 | Faghihet al (2009) Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the α7 nicotinic acetylcholine receptor. J.Med.Chem. 28 3377. PMID: 19419141. Malyszet al (2009) In vitro pharmacological characterization of a novel allosteric modulator of α 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile. J.Pharmacol.Exp.Ther. 330 257. PMID: 19389923. |