A 1070722 (50 MG)
货号：
4431/50 基本售价：
11233.1 元 规格：
50 mg
产品信息
概述| 货号 | 4431/50 |
| 别名 | 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea |
性能| 供应商 | Tocris |
| 生物活性 | Potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β). Displays high selectivity (> 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Decreases phosphorylation of microtubule-associated protein Tau in vitro; protects rat primary cortical neurons against β amyloid and glutamate challenge. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 362.31 |
| 分子式 | C17H13F3N4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Bakkeret al (2011) A-1070722, a potent, selective, and centrally active glycogen synthase kinase-3 (GSK-3) inhibitor for the treatment of psychiatric and neurodegenerative disorders. Society for Neuroscience (Abstract) 568. |
