PCI 34051
货号：
10444-100mg 基本售价：
11172.0 元 规格：
100 mg
产品信息
概述| 货号 | 10444-100mg |
| 描述 | PCI 34051 is a potent histone deacetylase (HDAC) 8 inhibitor (IC50 = 0.01 μM) with >200-fold selectivity over HDAC isoforms 1, 2, 3, 6, and 10 (IC50s = 4, >50, >50, 2.9, and 13 μM, respectively).1 PCI 34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias (GI50s = 2.4 - 4 μM), but not in other hematopoietic or solid tumor lines.1 This compound has also been used to support a critical role for HDAC8 in the coordinated deacetylation of the core cohesion component SMC3 during mitosis.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Balasubramanian, S.,Ramos, J.,Luo, W., et al. A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas. Leukemia 22(5), 1026-1034 (2008).
2.Deardorff, M.A.,Bando, M.,Nakato, R., et al. HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle. Nature 489, 313-317 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 296.3 |
| 分子式 | C17H16N2O3 |
| CAS号 | 950762-95-5 |
| 稳定性 | ≥ 2 years |
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