N-(α-Linolenoyl) Tyrosine
货号：
10032-100mg 基本售价：
11172.0 元 规格：
100 mg
产品信息
概述| 货号 | 10032-100mg |
| 描述 | Certain chronic neurologic disorders, such as Parkinson’s disease, are caused by an insufficiency of the neurotransmitter dopamine secondary to the degeneration of substantia nigra dopaminergic neurons.1 N-(α-Linolenoyl) tyrosine (NALT) is a simple α-amide conjugate between the ω-3 essential fatty acid α-linolenate and the amino acid tyrosine. α-Linolenate is an important precursor to docosahexaenoic acid (DHA), a prominent brain polyunsaturated fatty acid, while tyrosine is the metabolic precursor for neuronal dopamine synthesis. NALT was prepared as a method for enhancing central nervous system (CNS) dopamine content by facilitated transport of the tyrosine precursor across the blood-brain barrier.2 In experimental rat models of dopamine insufficiency, NALT increased CNS dopamine levels and exhibited an activity profile consistent with an anti-Parkinson’s therapeutic agent.2 |
| 别名 | NALT; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Martin, J.B. Molecular basis of the neurodegenerative disorders. New England Journal of Medicine 340, 1970-1980 (1999).
2.Yehuda, S. Possible anti-Parkinson properties of N-(α-linolenoyl) tyrosine: A new molecule. Pharmacology, Biochemistry, and Behavior 72, 7-11 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 441.6 |
| 分子式 | C27H39NO4 |
| CAS号 | 259143-19-6 |
| 稳定性 | ≥ 1 year |
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