I-BRD9
货号：
17749-50mg 基本售价：
11158.0 元 规格：
50 mg
产品信息
概述| 货号 | 17749-50mg |
| 描述 | BRD9 contains a single bromodomain and has five isoforms that are produced by alternative splicing.1 It is thought to function in chromatin remodeling as part of the SWI/SNF complex. I-BRD9 is a BRD9 bromodomain inhibitor with a pIC50 value of 7.3 and a pKd value of 8.7.2 It displays 700-fold greater selectivity over the tandem bromodomain-containing BET family of proteins and 200-fold selectivity over the highly homologous BRD7 bromodomain.2 This compound has been used to identify genes regulated by BRD9 in Kasumi-1 cells involved in cancer and immune response signaling.2 See the Structural Genomics Consortium (SGC) website for more information. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Muller, S.,Filippakopoulos, P., and Knapp, S. Bromodomains as therapeutic targets. Expert Rev.Mol.Med. 13, 1-21 (2011).
2.Theodoulou, N.H.,Bamborough, P.,Bannister, A.J., et al. Discovery of I-BRD9, a selective cell active chemical probe for bromodomain containing protein 9 inhibition. Journal of Medicinal Chemistry (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 497.6 |
| 分子式 | C22H22F3N3O3S2 |
| CAS号 | 1714146-59-4 |
| 稳定性 | ≥ 2 years |
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