DA-3003-2
货号：
17282-25mg 基本售价：
11144.0 元 规格：
25 mg
产品信息
概述| 货号 | 17282-25mg |
| 描述 | Cdc25 dual-specific protein tyrosine phosphatases are important for cell cycle progression and often overexpressed in cancers. Through the removal of inhibitory phosphates, they function to catalyze the activation of cyclin-Cdk complexes. DA-3003-2 is a Cdc25 phosphatase inhibitor (IC50 = 0.82 µM for human recombinant Cdc25B) that demonstrates antiproliferative activity.1,2,3 At 20 µM, it has been shown to arrest asynchronous PC-3 prostate cancer cells in G2/M phase.3 |
| 别名 | NSC 663285; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lazo, J.S.,Aslan, D.C.,Southwick, E.C., et al. Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. Journal of Medicinal Chemistry 44, 4042-4049 (2001).
2.Lavecchia, A.,Cosconati, S.,Limongelli, V., et al. Modeling of Cdc25B dual specifity protein phosphatase inhibitors: Docking of ligands and enzymatic inhibition mechanism. ChemMedChem 1(5), 540-550 (2006).
3.Nemoto, K. G2/M accumulation in prostate cancer cell line PC-3 is induced by Cdc25 inhibitor 7-chloro-6-(2-morpholin-4-ylethylamino) quinoline-5, 8-dione (DA 3003-2). Exp.Ther.Med. 1(4), 647-650 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 321.8 |
| 分子式 | C15H16ClN3O3 |
| CAS号 | 383907-47-9 |
| 稳定性 | ≥ 2 years |
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