α-hydroxy Farnesyl Phosphonic Acid
货号：
63420-10mg 基本售价：
11088.0 元 规格：
10 mg
产品信息
概述| 货号 | 63420-10mg |
| 描述 | α-hydroxy Farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl transferase (FTase).1,2 At concentrations greater than 1 µM, α-hydroxy farnesyl phosphonic acid inhibits the processing of Ras in Ha-ras-transformed NIH3T3 cells.3 |
| 别名 | Hydroxyfarnesyl Phosphate; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Pompliano, D.L.,Rands, E.,Schaber, M.D., et al. Steady-state kinetic mechanism of ras farnesyl: Protein transferase. Biochemistry 31, 3800-3807 (1992).
2.Hohl, R.J.,Lewis, K.A.,Cermak, D.M., et al. Stereochemistry-dependent inhibition of Ras farnesylation by farnesylphosphonic acids. Lipids 33, 39-46 (1998).
3.Gibbs, J.B.,Pompliano, D.L.,Mosser, S.D., et al. Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo. The Journal of Biological Chemisty 268(11), 7617-7620 (1993).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 302.4 |
| 分子式 | C15H27O4P |
| CAS号 | 148796-53-6 |
| 稳定性 | ≥ 1 year |
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