| 货号 | 34590-250ug |
| 描述 | 12(S)-HHTrE is a product of the cyclooxygenase (COX) pathway and one of the primary arachidonic acid metabolites of human platelets.1 It is biosynthesized by thromboxane (TXA2) synthase from prostaglandin H2(PGH2) concurrently with TXA2. 12(S)-HHTrE is a natural lipid agonist of the leukotriene B2 receptor BLT2in vivo that induces chemotaxis of mast cells and accelerates wound closure.2,3 12(S)-HHTrE is avidly oxidized to 12-oxoHTrE by porcine 15-hydroxy PGDH.4 |
| 别名 | 12(S)-HHT; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Diczfalusy, U.,Falardeau, P., and Hammarström, S. Conversion of prostaglandin endoperoxides to C17-hydroxy acids catalyzed by human platelet thromboxane synthase. FEBS Letters 84, 271-274 (1977). 2.Okuno, T.,Iizuka, Y.,Okazaki, H., et al. 12(S)-hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2. Journal of Experimental Medicine 1-8 (2008). 3.Liu, M.,Saeki, K.,Matsunobu, T., et al. 12-hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor. Journal of Experimental Medicine 211(6), 1063-1078 (2014). 4.Liu, Y.,Yoden, K.,Shen, R.F., et al. 12-L-Hydroxy-5,8,10-heptadecatrienoic acid (HHT) is an excellent substrate for NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. Biochemical and Biophysical Research Communications 129, 268-274 (1985). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 280.4 |
| 分子式 | C17H28O3 |
| CAS号 | 54397-84-1 |
| 稳定性 | ≥ 1 year |
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