TNF-α Antagonist
货号：
17492-5mg 基本售价：
11088.0 元 规格：
5 mg
产品信息
概述| 货号 | 17492-5mg |
| 描述 | TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor.1 By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α’s recruitment and activation of osteoclasts.2 TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destruction.2 |
| 别名 | WP9QY; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Takasaki, W.,Kajino, Y.,Kajino, K., et al. Structure-based design and characterization of exocyclic peptidomimetics that inhibit TNFα binding to its receptor. Nat.Biotechnol. 15, 1266-1270 (1997).
2.Aoki, K.,Saito, H.,Itzstein, C., et al. A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss. Journal of Clinical Investigation 116(6), 1525-1534 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 计算分子量 | 1226.4 |
| 分子式 | C58H71N11O15S2 |
| CAS号 | 199999-60-5 |
| 稳定性 | ≥ 2 years |
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