| 货号 | 16036-10mg |
| 描述 | Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacarandaplants.1 Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid (Item No. 90220). Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 µM).2,3,4 It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant α-tocopherol, suggesting that apoptosis results from oxidative stress.3,4 Jacaric acid is metabolized in vivo to conjugated linoleic acid (Item No. 90140), which is also cytotoxic to cancer cells.5 Jacaric acid inhibits cyclooxygenase-1 in vitro(Ki = 1.7 µM) and, with long term feeding, decreases stearoyl-CoA desaturase expression and activity in mice.6,7 |
| 别名 | 8(Z),10(E),12(Z)-Octadecatrienoic Acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Miranda, J.,Fernández-Quintela, A.,Macarulla, M.T., et al. A comparison between CLNA and CLA effects on body fat, serum parameters and liver composition. J.Physiol.Biochem. 65(1), 25-32 (2009). 2.Gasmi, J. and Sanderson, J.T. Jacaric acid and its octadecatrienoic acid geoisomers induce apoptosis selectively in cancerous human prostate cells: A mechanistic and 3-D structure-activity study. Phytomedicine 20(8-9), 734-742 (2013). 3.Yamasaki, M.,Motonaga, C.,Yokoyama, M., et al. Induction of apoptotic cell death in HL-60 cells by jacaranda seed oil derived fatty acids. J.Oleo Sci. 62(11), 925-932 (2013). 4.Liu, W.N. and Leung, K.N. Jacaric acid inhibits the growth of murine macrophage-like leukemia PU5-1.8 cells by inducing cell cycle arrest and apoptosis. Cancer Cell Int. 15, (2015). 5.Shultz, T.D.,Chew, B.P.,Seaman, W.R., et al. Inhibitory effect of conjugated dienoic derivatives of linoleic acid and β-carotene on the in vitro growth of human cancer cells. Cancer Letters 63, 125-133 (1992). 6.Mashhadi, Z.,Boeglin, W.E. and Brash, A.R. Robust inhibitory effects of conjugated linolenic acids on a cyclooxygenase-related linoleate 10S-dioxygenase: Comparison with COX-1 and COX-2. Biochim.Biophys.Acta. 1851(10), 1346-1352 (2015). 7.Shinohara, N.,Ito, J.,Tsuduki, T., et al. Jacaric acid, a linolenic acid isomer with a conjugated triene system, reduces stearoyl-CoA desaturase expression in liver of mice. J.Oleo Sci. 61(8), 433-441 (2012). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 278.4 |
| 分子式 | C18H30O2 |
| CAS号 | 28872-28-8 |
| 稳定性 | ≥ 2 years |
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