CAY10498
货号：
10007955-5mg 基本售价：
11088.0 元 规格：
5 mg
产品信息
概述| 货号 | 10007955-5mg |
| 描述 | The A1, A2A, A2B, and A3 adenosine receptors (ARs) are ubiquitous G protein-coupled receptors. The four AR subtypes have been implicated in several areas of therapeutic interest such as stroke and other ischemic conditions, as well as inflammation, neurodegenerative diseases, diabetes, and sleep regulation.1A3 AR antagonists are of interest as therapeutic agents in glaucoma agents and inflammation. CAY10498 is a potent and selective A3 AR antagonist exhibiting a Ki of 37 nM with 60 and 200-fold selectivity over A1 and A2A adenosine receptors, respectively.1 CAY10498 is also a structural analog of reversine, a dedifferentiation agent of embryonic progenitor cells.2 However, no dedifferentiation effects or any connection between A3 AR antagonism and dedifferentiation have been demonstrated. |
| 别名 | 2-phenyl-amino-N6-endo-norbornyladenine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Perreira, M.,Jiang, J.k.,Klutz, A.M., et al. "Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. Journal of Medicinal Chemistry 48, 4910-4918 (2005).
2.Chen, S.,Zhang, Q.,Wu, X., et al. Dedifferentiation of lineage-committed cells by a small molecule. Journal of the American Chemical Society 126, 410-411 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 320.4 |
| 分子式 | C18H20N6 |
| CAS号 | 863202-33-9 |
| 稳定性 | ≥ 1 year |
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