| 货号 | 5982/50 |
| 别名 | cis-2-Amino-2-(2-chlorophenyl)-6-hy |
| 供应商 | Tocris |
| 生物活性 | Metabolite of ketamine (Cat.No. 3131). Increases AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices. Exhibits antidepressive effects in vivo. 2S,2S- and 2R,6R-enantiomers available. 2R,6R-enantiomer lacks ketamine-related side effects. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 276.16 |
| 分子式 | C12H14ClNO2.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Zanoset al (2016) NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature 533 481. PMID: 27144355. Leung and Baillie (1986) Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine. J.Med.Chem. 29 2396. PMID: 3783598. |