| 货号 | 4624/50 |
| 别名 | N-(4-Chlorophenyl)-N-[2,3-dihydro-1 |
| 供应商 | Tocris |
| 生物活性 | Potent formyl peptide receptor 2 (FPR2) agonist (EC50 = 44 nM). Inhibits fMLP- and IL-8-induced neutrophil migration. Suppresses inflammation in a mouse model of acute inflammation. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 384.86 |
| 分子式 | C20H21ClN4O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Forsmanet al (2011) Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound library. Biochem.Pharmacol. 81 402. PMID: 21095183. Duftonet al (2010) Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation. J.Immunol. 184 2611. PMID: 20107188. Bürliet al (2006) Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents. Bioorg.Med.Chem.Lett. 16 3713. PMID: 16697190. |