| 货号 | 4886/50 |
| 别名 | 2-((2-Methylbutyl)amino)-1-(4-((3-m |
| 供应商 | Tocris |
| 生物活性 | Hedgehog acyltransferase (Hhat) inhibitor (IC50 = 850 nM). Inhibits Sonic Hedgehog N (ShhN) palmitoylation in vitro. Has no effect on porcupine-induced fatty acid acylation of Wnt39a. Attenuates pancreatic cancer cell proliferation. Cell permeable. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 423.01 |
| 分子式 | C22H30N2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Petrovaet al (2014) Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene 34 263. PMID: 24469057. Petrovaet al (2013) Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. Nat.Chem.Biol. 9 247. PMID: 23416332. |