| 货号 | 5083/50 |
| 别名 | 5-(2,6-Dichloro-5-fluoro-3-pyridiny |
| 供应商 | Tocris |
| 生物活性 | Kv7 channel opener (EC50 values are 0.6, 1.0, 5.2 and 7.0 μM for Kv7.4, Kv7.2, Kv7.3/7.5 and Kv7.1, respectively). Increases the pain threshold of neuropathic pain in a sciatic nerve CCI in vivomodel. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 443.18 |
| 分子式 | C18H8Cl2F4 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Zhanget al (2013) Modulation of Kv7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58. Br.J.Pharmacol. 168 1030. PMID: 23013484. Qiet al (2011) Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators. Eur.J.Med.Chem. 46 934. PMID: 21296466. |