| 货号 | 4569/50 |
| 别名 | N-(6-Chloro-9H-pyrido[3,4-b]indol-8 |
| 供应商 | Tocris |
| 生物活性 | Selective IκB kinase (IKK) inhibitor (IC50 = 100 nM). Has no effect on PKA, PKC and CKII activity. Inhibits IκB-α phosphorylation and NFκB activation in HeLa cells. Inhibits NFκB-mediated proinflammatory gene expression in human airway epithelial cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line. Attenuates LPS-induced TNF-αproductionin vivo. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 395.67 |
| 分子式 | C17H11ClN4O.2HCl |
| 可溶性/溶解性 | Soluble to 5 mM in DMSO with gentle warming |
| 参考文献 | Newtonet al (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors. J.Pharmacol.Exp.Ther. 321 734. PMID: 17322026. Castroet al (2003) Novel IKK inhibitors: beta-carbolines. Bioorg.Med.Chem.Lett. 13 2419. PMID: 12824047. Hideshimaet al (2002) NF-kappa B as a therapeutic target in multiple myeloma. J.Biol.Chem. 277 16639. PMID: 11872748. |