| 货号 | 5575/50 |
| 别名 | 11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt |
| 供应商 | Tocris |
| 生物活性 | JNK inhibitor (Kd values are 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Inhibits LPS-induced proinflammatory cytokine and nitric oxide production in vitro. Attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivity in vivo. Anti-inflammatory and immunosuppressive. Also releases NO upon metabolism by liver microsomes. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 269.23 |
| 分子式 | C15H8N3NaO |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO with gentle warming |
| 参考文献 | Atochinet al (2016) A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia-reperfusion injury in mice. Neurosci.Lett. 618 45. PMID: 26923672. Schepetkinet al (2015) Anti-Inflammatory effects and joint protection in collagen-induced arthritis after treatment with IQ-1S, a selective c-Jun N-terminal kinase Inhibitor. J.Pharmacol.Exp.Ther. 353 505. PMID: 25784649. Schepetkinet al (2012) Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol.Pharmacol. 81 832. PMID: 22434859. |