Dianicline (50 MG)
货号：
5557/50 基本售价：
11084.4 元 规格：
50 mg
产品信息
概述| 货号 | 5557/50 |
| 别名 | (5aS,8S,10aR)-5a,6,9,10-Tetrahydro-7H,11H-8,10a-methanopyrido[2',3':5,6]pyrano[2,3-d]azepine |
性能| 供应商 | Tocris |
| 生物活性 | Selectiveα4β2 nAChR partial agonist (IC50 = 105 nM). Exhibits >20-fold selectivity for α4β2 over other nAChR subtypes. Increases dopamine turnover in rat nucleus accumbens in vivo. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 289.2 |
| 分子式 | C13H16N2O.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 20 mM in DMSO |
| 参考文献 | Rollemaet al (2010) Pre-clinical properties of the α4β2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence. Br.J.Pharmacol. 160 334. PMID: 20331614. |
