| 货号 | 4609/50 |
| 别名 | 3,5-Dichloro-2-hydroxy-N-(4-methoxy |
| 供应商 | Tocris |
| 生物活性 | ATP citrate lyase (ACL) inhibitor (IC50 = 0.13 μM for human recombinant ACL); blocks lipid synthesis (IC50 = 8 μM in HepG2 cells). Displays no cytotoxicity up to a concentration of 50 μM. Lowers plasma glucose and triglycerides in a mouse model of hyperlipidemia. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 424.3 |
| 分子式 | C19H15Cl2NO4 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO and to 50 mM in ethanol |
| 参考文献 | Maet al (2009) A novel direct homogeneous assay for ATP citrate lyase. J.Lipid Res. 50 2131. PMID: 19286649. Liet al (2007) 2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors. Bioorg.Med.Chem.Lett. 17 3208. PMID: 17383874. |