| 货号 | 4778/50 |
| 别名 | 2-(Ethylsulfinyl)-4-[3-(phenylmetho |
| 供应商 | Tocris |
| 生物活性 | Selective positive allosteric modulator and partial agonist of the glucagon-like peptide 1 (GLP-1) receptor. Increases binding affinity of oxyntomodulin for the GLP-1 receptor. Potentiates oxyntomodulin-mediated GLP-1 receptor signaling in vitro and insulin secretion in vivo. Has no effect on GLP-2, GIP, PTH or glucagon receptors. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 406.42 |
| 分子式 | C20H17F3N2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| 参考文献 | Cheonget al (2012) Two small molecule agonists of glucagon-like peptide-1 receptor modulate the receptor activation response differently. Biochem.Biophys.Res.Comm. 417 558. PMID: 22177947. Willardet al (2012) Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin. Mol.Pharmacol. 82 1066. PMID: 22930710. Sloopet al (2010) Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets. Diabetes 59 3099. PMID: 20823098. |