| 货号 | 5079/50 |
| 别名 | 2-Methyl-3-[(2S)-pyrrolidinylmethox |
| 供应商 | Tocris |
| 生物活性 | High affinity and selective α4β2 partial agonist (Ki = 16 nM). Exhibits >1000-fold and >10,000-fold selectivity for α4β2 over α1β1γ1 and α7 receptors respectively. Neuroprotective against glutamate-induced toxicity in rat cortical neurons in vitro. Enhances cognitive performance in vivo. Orally bioavailable and brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 265.18 |
| 分子式 | C11H16N2O.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 20 mM in DMSO |
| 参考文献 | Rueteret al (2004) ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine receptor agonist for the potential treatment of cognitive disorders. CNS Drug Rev. 10 167. PMID: 15179445. Deckeret al (1997) ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys. J.Pharmacol.Exp.Ther. 283 247. PMID: 9336330. Sullivanet al (1997) ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties. J.Pharmacol.Exp.Ther. 283 235. PMID: 9336329. |