| 货号 | 3250/50 |
| 别名 | 3-(2,5-Difluorophenyl)-7-(1,1-dimet |
| 供应商 | Tocris |
| 生物活性 | Subtype-selective GABAA receptor partial agonist. Selectively binds to α1,α2,α3 and α5 subunits (Ki values are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at α1 (α1-sparing). Exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 399.4 |
| 分子式 | C19H19F2N7O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in ethanol with sonication |
| CAS号 | 286456-42-6 |
| 参考文献 | Knablet al (2008) Reversal of pathological pain through specific spinal GABAA receptor subtypes. Nature 451 330. PMID: 18202657. McMahon and France (2006) Differential behavioural effects of low efficacy positive GABAA modulators in combination with benzodiazepines and a neuroactive steroid in rhesus monkeys. Br.J.Pharmacol. 147 260. PMID: 16331290. McCabeet al (2004) Subtype-selective GABAergic drugs facilitate extinction of mouse operant behaviour. Neuropharmacology 46 171. PMID: 14680756. |