Odanacatib
货号：
21466-25mg 基本售价：
11032.0 元 规格：
25 mg
产品信息
概述| 货号 | 21466-25mg |
| 描述 | Odanacatib is a potent, selective, and neutral inhibitor of cathepsin K (IC50s = 0.2 and 1 nM for human and rabbit enzymes, respectively), a protease involved in osteoclastic bone resorption.1 It demonstrates high selectivity for cathepsin K over cathepsins B, L, and S. Formulations containing odanacatib reduce bone resorption, with lesser reductions in bone formation, resulting in increased bone mineral density.2,3 |
| 别名 | MK-0822; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gauthier, J.Y.,Chauret, N.,Cromlish, W., et al. The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. Bioor. Med. Chem. Lett. 18(3), 923-928 (2008).
2.Chapurlat, R.D. Odanacatib: A review of its potential in the management of osteoporosis in postmenopausal women. Ther. Adv. Musculoskelet. Dis. 7(3), 103-109 (2015).
3.Rachner, T.D.,Khosla, S. and Hofbauer, L.C. New horizons in osteoporosis. Lancet. 377(9773), 1276-1298 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 525.6 |
| 分子式 | C25H27F4N3O3S |
| CAS号 | 603139-19-1 |
| 稳定性 | ≥ 2 years |
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