CAY10706
货号：
19318-5mg 基本售价：
11032.0 元 规格：
5 mg
产品信息
概述| 货号 | 19318-5mg |
| 描述 | CAY10706 is a ligustrazine-curcumin hybrid that promotes intracellular reactive oxygen species accumulation preferentially in lung cancer cells.1 It has been shown to inhibit the proliferation of drug-sensitive (A549 (IC50 = 2.19 µM), SPC-A-1 (IC50 = 3.12 µM), LTEP-G-2 (IC50 = 2.88 µM)) and drug-resistant (A549/DDP (IC50 = 0.6 µM)) lung cancer cells but demonstrates little effect on non-tumor lung epithelial-like cells (HBE (IC50 = 21.34 µM)).1 CAY10706 can suppress the thioredoxin reductase system and inhibit the NF-κB, Akt, and ERK signaling.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ai, Y.,Zhu, B.,Ren, C., et al. Discovery of new monocarbonyl ligustrazine-curcumin hybrids for intervention of drug-sensitive and drug-resistant lung cancer. J. Med. Chem. 59(5), 1747-1760 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 324.4 |
| 分子式 | C19H20N2O3 |
| CAS号 | 1881270-27-4 |
| 稳定性 | ≥ 2 years |
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