| 货号 | 18752-5mg |
| 描述 | Aureusimine B, also known as phevalin, is a natural pyrazinone produced by certain fungi and by Staphylococcus spp., including S. aureus.1,2 Its synthesis appears to be initiated by a conserved nonribosomal peptide synthetase that creates a dipeptide (phenylalanine-valine) aldehyde, which then undergoes cyclization and oxidation.2 Aureusimine B inhibits calpain in a casein hydrolysis assay (IC50 = 1.3 µM), contributes to S. aureus infection in mice, and alters human keratinocyte gene expression.1,3,4 |
| 别名 | Phevalin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Alvarez, M.E.,White, C.B.,Gregory, J., et al. Phevalin, a new calpain inhibitor, from a Streptomyces sp. J.Antibiot.(Tokyo) 48(10), 1165-1167 (1995). 2.Zimmermann, M. and Fischbach, M.A. A family of pyrazinone natural products from a conserved nonribosomal peptide synthetase in Staphylococcus aureus. Chemistry & Biology 17(9), 925-930 (2010). 3.Secor, P.R.,Jennings, L.K.,James, G.A., et al. Phevalin (aureusimine B) production by Staphylococcus aureus biofilm and impacts on human keratinocyte gene expression. PLoS One 7(7), (2012). 4.Wyatt, M.A.,Wang, W.,Roux, C.M., et al. Staphylococcus aureus nonribosomal peptide secondary metabolites regulate virulence. Science 329(5989), 294-296 (2010). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 228.3 |
| 分子式 | C14H16N2O |
| CAS号 | 170713-71-0 |
| 稳定性 | ≥ 2 years |
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