GDC-0068
货号：
18412-25mg 基本售价：
11032.0 元 规格：
25 mg
产品信息
概述| 货号 | 18412-25mg |
| 描述 | GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays.1 It is 620-fold selective for Akt over protein kinase A and has been shown to block Akt signaling selectively in cultured tumor cell lines characterized by activated Akt, halting cell cycle progression and reducing cell viability.1 In multiple tumor xenograft models, oral administration of GDC-0068 at 100 mg/kg/day can lead to delayed tumor growth and regression.1 |
| 别名 | Ipatasertib;RG-7440; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lin, J.,Sampath, D.,Nannini, M.A., et al. Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models. Clinical Cancer Research 19(7), 1760-1772 (2016).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 458 |
| 分子式 | C24H32ClN5O2 |
| CAS号 | 1001264-89-6 |
| 稳定性 | ≥ 2 years |
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