CX-5461
货号：
18392-50mg 基本售价：
11032.0 元 规格：
50 mg
产品信息
概述| 货号 | 18392-50mg |
| 描述 | CX-5461 is an inhibitor of ribosomal RNA (rRNA) synthesis. It selectively inhibits RNA polymerase I-driven transcription of rRNA in HCT116, A375, and MIA PaCa-2 tumor cells (IC50s = 142, 113, and 54 nM, respectively) without affecting RNA polymerase II (IC50 > 25µM), DNA replication, or protein translation.1,2 At 50 mg/kg, CX-5461 demonstrates in vivo antitumor activity against human solid tumors in mouse xenograft models.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Drygin, D.,Lin, A.,Bliesath, J., et al. Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth. Cancer Research 71(4), 1418-1430 (2011).
2.Haddach, M.,Schwaebe, M.K.,Michaux, J., et al. Discovery of CX-5461, the first direct and selective inhibitor of RNA polymerase I, for cancer therapeutics. ACS Med.Chem.Lett. 3(7), 602-606 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 513.6 |
| 分子式 | C27H27N7O2S |
| CAS号 | 1138549-36-6 |
| 稳定性 | ≥ 2 years |
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