MS023 (hydrochloride)
货号：
18361-25mg 基本售价：
11032.0 元 规格：
25 mg
产品信息
概述| 货号 | 18361-25mg |
| 描述 | Protein arginine methyltransferases (PRMTs) post-translationally modify proteins, including histones, and in this way regulate gene expression, signal transduction, and protein-protein interactions.1 MS023 is a potent, selective inhibitor of type I PRMTs (IC50s = 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectively).2 It is inactive against type II and type III PRMTs, as well as other types of MTs. MS023 is active in cells, inhibiting the dimethylation of histone 4 at Arg3 by PRMT1 with an IC50 value of 9 nM.2 See the Structural Genomics Consortium (SGC) website for more information. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yang, Y. and Bedford, M.T. Protein arginine methyltransferases and cancer. Nature Reviews.Cancer 13(1), 37-50 (2013).
2.Eram, M.S.,Shen, Y.,Szewczyk, M.M., et al. A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases. ACS Chemical Biology 11.8.15, (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 396.8 |
| 分子式 | C17H25N3O • 3HCl |
| 稳定性 | ≥ 2 years |
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