EGFR Inhibitor
货号：
15363-25mg 基本售价：
11032.0 元 规格：
25 mg
产品信息
概述| 货号 | 15363-25mg |
| 描述 | EGFR inhibitor is a cell permeable, 4,6-disubstituted pyrimidine compound that selectively inhibits the EGFR kinase with an IC50 value of 21 nM in vitro and blocks receptor autophosphorylation in cells.1 It can also inhibit the L858R and L861Q EGFR mutants (IC50s = 63 and 4 nM, respectively) yet displays strong selectivity for EGFR against a panel of 55 recombinant kinases (IC50s > 10 μM).1 Whereas overactivity of EGFR tyrosine kinases has been associated with a number of cancers, inhibition of EGFR has been shown to induce apoptosis by downregulating antiapoptotic proteins such as survivin and upregulating proapoptotic proteins such as Bim.2,3 |
| 别名 | Epidermal Growth Factor Receptor Inhibitor; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zhang, Q.,Liu, Y.,Gao, F., et al. Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library. Journal of the American Chemical Society 128(7), 2182-2183 (2006).
2.Ciardiello, F. and Tortora, G. EGFR antagonists in cancer treatment. New England Journal of Medicine 358(11), 1160-1174 (2008).
3.Okamoto, K.,Okamoto, I.,Okamoto, W., et al. Role of survivin in EGFR inhibitor-induced apoptosis in non-small cell lung cancers positive for EGFR mutations. Cancer Research 70(24), 10402-10410 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 413.4 |
| 分子式 | C21H18F3N5O |
| CAS号 | 879127-07-8 |
| 稳定性 | ≥ 2 years |
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