STK393606
货号：
14049-25mg 基本售价：
11032.0 元 规格：
25 mg
产品信息
概述| 货号 | 14049-25mg |
| 描述 | 15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH) is a key enzyme involved in the inactivation of PGs and related eiscosanoids.1 It functions by catalyzing the oxidation of primary PGs to their 15-keto metabolites. Two types of 15-hydroxy PGDH have been identified: type-I is NAD+-dependent primarily using eicosanoids as substrates, while type-II uses either NAD+ or NADP+ as cofactors and bears broader substrate specificity.1 STK393606 is a competitive inhibitor of NAD+-dependent type-I 15-hydroxy PGDH with an IC50 value of 26.4 nM and a Ki value of 5 nM.2 It demonstrates selectivity for 15-hydroxy PGDH when profiled across a panel of related dehydrogenase or reductase enzymes.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tai, H.H.,Ensor, C.M.,Tong, M., et al. Prostaglandin catabolizing enzymes. Prostaglandins & Other Lipid Mediators 68-69, 483-493 (2002).
2.Niesen, F.H.,Schultz, L.,Jadhav, A., et al. High-affinity inhibitors of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase: Mechanisms of inhibition and structure-activity relationships. PLoS One 5(11), 1-12 (2010).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 345.2 |
| 分子式 | C14H9BrN4S |
| CAS号 | 355827-05-3 |
| 稳定性 | ≥ 2 years |
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