| 货号 | 10009039-100ug |
| 描述 | tetranor-PGDM-d6 contains six deuterium atoms at the 17, 17, 18, 18, 19 and 19 positions. It is intended for use as an internal standard for the quantification of tetranor-PGDM by GC- or LC-mass spectrometry (MS). Prostaglandin D2(PGD2) is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.1PGD2 is also produced in the brain by lipocalin PGD-synthase also known as β-trace.2,3 In the brain, PGD2 produces normal physiological sleep and lowering of body temperature.2,3 Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle.4 tetranor-PGDM is a major metabolite of PGD2 that is detectable in human and murine urine.5 The levels of tetranor-PGDM and 2,3-dinor-11b-PGF2α, a related PGD2 metabolite, in human urine were found to be 1.5 ± 0.3 and 0.6 ± ng/mg creatinine, respectively. tetranor-PGDM was detected in mouse urine at a level of 8.1 ± 1.3 ng/mg creatinine.5 |
| 别名 | tetranor-Prostaglandin D Metabolite-d6; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Roberts, L.J., II, and Sweetman, B.J. Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosis. Prostaglandins 30, 383-400 (1985). 2.Hayaishi, O. Sleep-wake regulation by prostaglandins D2 and E2. The Journal of Biological Chemisty 263, 14593-14596 (1988). 3.Onoe, H.,Ueno, R.,Fujita, I., et al. Prostaglandin D2, a cerebral sleep-inducing substance in monkeys. Proceedings of the National Academy of Sciences of the United States of America 85, 4082-4086 (1988). 4.Giles, H., and Leff, P. The biology and pharmacology of PGD2. Prostaglandins 35, 277-300 (1988). 5.Song, W.L.,Wang, M.,Ricciotti, E., et al. Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans. The Journal of Biological Chemisty 283(2), 1179-1188 (2008). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥99% deuterated forms (d1-d6) |
| 计算分子量 | 334.4 |
| 分子式 | C16H18O7D6 |
| CAS号 | 1314905-92-4 |
| 稳定性 | ≥ 6 months |
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