Bromoenol lactone
货号：
70700-50mg 基本售价：
10976.0 元 规格：
50 mg
产品信息
概述| 货号 | 70700-50mg |
| 描述 | BEL is a selective, potent, irreversible, mechanism-based inhibitor of myocardial cytosolic calcium-independent phospholipase A2(iPLA2) with a Ki value of 180 nM.1 BEL also inhibits macrophage iPLA2 in a concentration-dependent manner with an IC50 value of 60 nM and is an effective enzyme-activated irreversible inhibitor of chymotrypsin (Ki = 636 nM).2,3 |
| 别名 | BEL;Haloenol lactone;HELSS; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hazen, S.L.,Zupan, L.A.,Weiss, R.H., et al. Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2. The Journal of Biological Chemisty 266, 7227-7232 (1991).
2.Ackermann, E.J.,Conde-Frieboes, K., and Dennis, E.A. Inhibition of macrophage Ca2+-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. The Journal of Biological Chemisty 270, 445-450 (1995).
3.Daniels, S.B.,Cooney, E.,Sofia, M.J., et al. Haloenol lactones. Potent enzyme-activated irreversible inhibitors for α-chymotrypsin. The Journal of Biological Chemisty 258, 15046-15053 (1983).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 317.2 |
| 分子式 | C16H13BrO2 |
| CAS号 | 88070-98-8 |
| 稳定性 | ≥ 1 year |
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