| 货号 | 63250-5mg |
| 描述 | Farnesyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway and used in the biosynthesis of terpenes, terpenoids, and sterols.1 It also serves as a donor in post-translational isoprenylation of proteins.2 FPP has been identified as an antagonist of P2Y12 receptors (IC50 = 45 μM), attenuating platelet aggregation.3 It has also been shown to regulate adipocyte function as an endogenous PPARγ agonist.4 Additionally, because of a flexible hydrocarbon chain that enables different conformations, FPP is a promiscuous ligand for a subset of nuclear receptors.5 |
| 别名 | FPP; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Vance, D.E. Cholesterol and related derivatives. Biochemistry 2nd ed., 725-748 (1988). 2.McTaggart, S.J. Isoprenylated proteins. Cell Mol.Life Sci. 63(3), 255-267 (2006). 3.Högberg, C.,Gidlöf, O.,Deflorian, F., et al. Farnesyl pyrophosphate is an endogenous antagonist to ADP-stimulated P2Y12 receptor-mediated platelet aggregation. Thrombosis and Haemostasis 108(1), 119-132 (2012). 4.Goto, T.,Nagai, H.,Egawa, K., et al. Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. Biochemistry Journal 438(1), 111-119 (2011). 5.Goyanka, R.,Das, S.,Samuels, H.H., et al. Nuclear receptor engineering based on novel structure activity relationships revealed by farnesyl pyrophosphate. Protein Eng.Des.Sel. 23(11), 809-815 (2010). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 433.4 |
| 分子式 | C15H25O7P2 • 3NH4 |
| CAS号 | 116057-57-9 |
| 稳定性 | ≥ 1 year |
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