EPZ011989
货号：
19161-5mg 基本售价：
10976.0 元 规格：
5 mg
产品信息
概述| 货号 | 19161-5mg |
| 描述 | The lysine methyltransferase EZH2 (KMT6), part of polycomb repressive complex 2, catalyzes trimethylation of lysine 27 on histone H3 and is involved in proliferation and aggressive cell growth associated with neoplastic cells.1 EPZ011989 is an orally bioavailable EZH2 inhibitor with Ki values that are less than 3 nM for wild type and Tyr646 mutated EZH2.2 It displays 15-fold selectivity for EZH2 over EZH1 and is without effect against an array of other lysine methyltransferases.2 EPZ011989 demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Simon, J.A., and Lange, C.A. Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutation Research 647, 21-29 (2008).
2.Campbell, J.E.,Kuntz, K.W.,Knutson, S.K., et al. EPZ011989, a potent, orally-available EZH2 inhibitor with robust in vivo activity. ACS Med.Chem.Lett. 6(5), 491-495 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 605.8 |
| 分子式 | C35H51N5O4 |
| CAS号 | 1598383-40-4 |
| 稳定性 | ≥ 2 years |
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