Syk Inhibitor II (hydrochloride)
货号：
18805-5mg 基本售价：
10976.0 元 规格：
5 mg
产品信息
概述| 货号 | 18805-5mg |
| 描述 | Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner.1 It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 µM, respectively).1 Syk inhibitor II has been shown to prevent FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro(IC50 = 460 nM) and to inhibit passive cutaneous anaphylaxis reactions in mice (ID50 = 13.2 mg/kg, s.c.).1 |
| 别名 | Spleen Tyrosine Kinase Inhibitor II; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hisamichi, J.,Naito, R.,Toyoshima, A., et al. Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives. Bioorganic & Medicinal Chemistry 13(16), 4936-4951 (2005).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 413.2 |
| 分子式 | C14H15F3N6O • 2HCl |
| CAS号 | 227449-73-2 |
| 稳定性 | ≥ 2 years |
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