Nocloprost
货号：
10988-5mg 基本售价：
10976.0 元 规格：
5 mg
产品信息
概述| 货号 | 10988-5mg |
| 描述 | Nocloprost is a stable prostaglandin E2 analog with gastroprotective and ulcer-healing properties. As a weak acid (pKa = 5), it accumulates in the gastric mucosa at low pH and can prevent the formation of gastric lesions in rats when administered intragastrically 30 minutes before 100% ethanol, acidified aspirin, acidified taurocholate, water immersion, or restraint stress (ID50s = 0.25, 0.58, 0.06 and 0.12 μg/kg, respectively).1 Additionally, nocloprost has been used to inhibit evoked acetylcholine release from isolated human bronchi (IC50 = 4 nM) to study factors that regulate human airway smooth muscle tone and secretion.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Konturek, S.J.,Brzozowski, T.,Drozdowicz, D., et al. Nocloprost, a unique prostaglandin E2 analog with local gastroprotective and ulcer-healing activity. European Journal of Pharmacology 195(3), 347-357 (1991).
2.Reinheimer, T.,Harnack, E.,Racke, K., et al. Prostanoid receptors of the EP3 subtype mediate inhibition of evoked [3H]acetylcholine release from isolated human bronchi. British Journal of Pharmacology 125(2), 271-276 (1998).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 401 |
| 分子式 | C22H37ClO4 |
| CAS号 | 79360-43-3 |
| 稳定性 | ≥ 1 year |
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