Benzisoxazole Hsp90 Inhibitor
货号：
10012694-10mg 基本售价：
10976.0 元 规格：
10 mg
产品信息
概述| 货号 | 10012694-10mg |
| 描述 | Heat shock protein 90 (Hsp90) is a molecular chaperone that modulates intracellular signaling and protein folding, trafficking, and turnover. Inhibitors of Hsp90, such as geldanamycin, have shown promise as anti-tumor agents. CAY10607 binds the N-terminal domain of Hsp90, efficiently displacing geldanamycin from the ATP binding site (IC50 = 30 nM).1 In addition, CAY10607 inhibits the proliferation of several cancer cell lines (IC50 ~ 0.28 μM), promotes the degradation of the Hsp90 client proteins Her-2 and androgen receptor, and has no effect on a variety of kinases.1 |
| 别名 | Benzisoxazole Hsp90 Inhibitor;BHI; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gopalsamy, A.,Shi, M.,Golas, J., et al. Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90. Journal of Medicinal Chemistry 51, 373-375 (2008).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 389.8 |
| 分子式 | C19H20ClN3O4 |
| CAS号 | 1012788-65-6 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
