fluoro-Dapagliflozin
货号：
15951-50mg 基本售价：
10920.0 元 规格：
50 mg
产品信息
概述| 货号 | 15951-50mg |
| 描述 | Dapagliflozin (Item No. 11573) is a selective sodium-glucose cotransporter (SGLT) inhibitor that blocks glucose transport with about 100-fold selectivity for SGLT2 (Ki = 6 nM; EC50 = 1.1 nM) over SGLT1 (Ki = 390 nM).1,2 It improves glucose tolerance in normal rats and reduces hyperglycemia in Zucker diabetic fatty rats.3 fluoro-Dapagliflozin is an analog of dapagliflozin that displays similar selectivity for inhibiting SGLT2 over SGLT1 (Kis = 5.3 and 330 nM, respectively).1 fluoro-Dapagliflozin (10 nM) significantly reduces phlorizin-sensitive sugar transport in COS-1 cells expressing human SGLT2.1 |
| 别名 | flouro-DAPA; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hummel, C.S.,Lu, C.,Liu, J., et al. Structural selectivity of human SGLT inhibitors. American Journal of Physiology.Cell Physiology 302(2), C373-C382 (2012).
2.Chao, E.C. and Henry, R.R. SGLT2 inhibition - A novel strategy for diabetes treatment. Nature Reviews.Drug Discovery 9(7), 551-559 (2010).
3.Han, S.,Hagan, D.L.,Taylor, J.R., et al. Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats. Diabetes 57(6), 1723-1729 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 410.9 |
| 分子式 | C21H24ClFO5 |
| CAS号 | 1181681-43-5 |
| 稳定性 | ≥ 2 years |
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