| 货号 | 13874-100mg |
| 描述 | Tenofovir is an analog of adenosine monophosphate that has antiviral activity.1,2 It is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase.3,4 Tenofovir diphosphate is a weak inhibitor of mammalian DNA polymerases α and β and mitochondrial DNA polymerase γ.4Forin vivo and cell culture use, tenofovir is supplied as a water soluble prodrug in the form of tenofovir disoproxil fumarate, which increases the intracellular diphosphorylated compound >1,000-fold above the level attained with unmodified tenofovir.4 |
| 别名 | GS-1275;GS-1278;(R)-PMPA;TDF; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Balzarini, J.,Vahlenkamp, T.,Egberink, H., et al. Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NMRI mice. Antimicrobial Agents and Chemotherapy 41(3), 611-616 (1997). 2.Balzarini, J.,Holy, A.,Jindrich, J., et al. Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: Potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine. Antimicrobial Agents and Chemotherapy 37(2), 332-338 (1993). 3.Van Gelder, J.,Shafiee, M.,De Clercq, E., et al. Species-dependent and site-specific intestinal metabolism of ester prodrugs. International Journal of Pharmacy 205(1-2), 93-100 (2000). 4.Robbins, B.L.,Srinivas, R.V.,Kim, C., et al. Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), bis(isopropyloxymethylcarbonyl)PMPA. Antimicrobial Agents and Chemotherapy 42(3), 612-617 (1998). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 287.2 |
| 分子式 | C9H14N5O4P |
| CAS号 | 147127-20-6 |
| 稳定性 | ≥ 2 years |
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