MEG (sulfate)
货号：
81020-100mg 基本售价：
10780.0 元 规格：
100 mg
产品信息
概述| 货号 | 81020-100mg |
| 描述 | MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively.1 MEG reacts with peroxynitrite with a second order rate constant of 1,900 M−1s−1 at 37°C.2 MEG has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of iNOS and as a scavenger of peroxynitrite.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Southan, G.J.,Zingarelli, B.,OConnor, M., et al. Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform. British Journal of Pharmacology 117, 619-632 (1996).
2.Szabó, C.,Ferrer-Sueta, G.,Zingarelli, B., et al. Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage. The Journal of Biological Chemisty 272, 9030-9036 (1997).
3.Cuzzocrea, S.,Zingarelli, B.,Hake, P., et al. Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation. Free Radical Biology & Medicine 24, 450-459 (1998).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥98% |
| 计算分子量 | 336.4 |
| 分子式 | [C3H9N3S]2 ?H2SO4 |
| CAS号 | 3979-00-8 |
| 稳定性 | ≥ 1 year |
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