UNC1215
货号：
13968-50mg 基本售价：
10780.0 元 规格：
50 mg
产品信息
概述| 货号 | 13968-50mg |
| 描述 | Methyllysine (Kme) recognition “reader” domains play a central role in epigenetic regulation during cellular differentiation, development, and gene transcription. UNC1215 is a potent and selective chemical probe for the Kme reading function of L3MBTL3, a member of the malignant brain tumor (MBT) family of chromatin interacting transcriptional repressors.1 UNC1215 binds L3MBTL3 with a Kd value of 120 nM (IC50 = 40 nM), competitively displacing mono- or dimethyl-lysine containing peptides.1 This probe is greater than 50-fold selective toward L3MBTL3 than other members of the human MBT family and demonstrates selectivity against more than 200 other Kme reader domains examined.1 See the Structural Genomics Consortium (SGC) website for more information. |
性能| 供应商 | Cayman |
| 应用文献 |
1.James, L.I.,Barsyte-Lovejoy, D.,Zhong, N., et al. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nature Chemical Biology 9(3), 184-191 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 529.7 |
| 分子式 | C32H43N5O2 |
| CAS号 | 1415800-43-9 |
| 稳定性 | ≥ 2 years |
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