Naphthofluorescein
货号：
13055-50mg 基本售价：
10780.0 元 规格：
50 mg
产品信息
概述| 货号 | 13055-50mg |
| 描述 | Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Naphthofluorescein is a cell-permeable inhibitor of furin (IC50 = 12 μM).1 It inhibits furin-mediated cleavage of the pro-form of membrane type-1 matrix metalloproteinase (MT1-MMP), resulting in decreased levels of active MT1-MMP.1 This, in turn, suppresses MMP-2 activation and reduces cell motility in CHO cells expressing proMT1-MMP.1 Napthofluorescein significantly inhibits the invasion of Matrigel by the human fibrosarcoma cell line, HT1080.1 The effects of this furin inhibitor on other furin-mediated processes, in vivoorin vitro, remain to be determined. |
| 别名 | CCG 8295; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Coppola, J.M.,Bhojani, M.S.,Ross, B.D., et al. A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness. Neoplasia 10(4), 363-370 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 432.4 |
| 分子式 | C28H16O5 |
| CAS号 | 61419-02-1 |
| 稳定性 | ≥ 2 years |
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